Monday, September 10, 2012

MODE OF ACTION

Many of the drugs we use today to cure illness are not known why they cure. Yes, trials and numerous studies were done before they even hit the market. But most of these trials were studies to determine the side effects of these drugs and their interactions with other drugs. We do not know how these drugs cure at the chemical level; where they go before they are excreted out of the body and be found in the urine, stools and in our saliva.We know how much of the drug is necessary to cure infection for example ( antibiotics). We know how many milligrams we need to bring down hypertension. We know how much tablets we have to give in order to bring down blood sugar to a desirable level. But there are drugs we really do not know the mode of action.
Take STEROIDS  for example. We use this drug as a last resort in some diseases like STATUS ASTHMATICUS or in ACUTE GLOMERULONEPHRITIS. How does steroid give relief to bronchospasm which is the main cause of ASTHMA? Yes, we know steroids bring down inflammation which is inherent in asthma. We know steroids decrease fluid secretions in the bronchus. But how about bronchospasm? Does it have a parasympathomimetic effect in the bronchus? Can anybody tell me?

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